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Figure 7.
Figure 7. Schematic representation showing the interaction
between Ca^2+ ATP and a mutant actin (half chimera-1). Water
molecules (pink spheres) are important for mediating both the
interaction between the adenine ring and actin and also for the
binding of the Ca^2+ and phosphate. The adenine base fits in a
hydrophobic pocket (yellow thick line) but many of its
hydrogen-bonded interactions with polar groups on actin are
mediated through water molecules. Similarly, the interactions of
Ca^2+ to acidic residues on actin such as aspartate residues 11
and 154 are mediated through water molecules. Broken cyan lines
correspond to hydrogen bonds or electrostatic interactions. The
corresponding distances in Å are given next to the broken
lines. The distance in Å between Wat203 and the
g-phosphorous is also given next to a black arrow.
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