Figure 7 - full size

 

Figure 7.
Figure 7 Stereoview of the environment behind the metal-binding site in the N lobe, showing the interactions of Lys210 and Lys301. Lys210 froms a hydrogen bond to Tyr192 and Tyr82 through a water molecule which is conserved in lactoferrins. Lys301 interacts with Glu216, Asp297 and the carbonyl O atom of Asp302. In transferrins, the corresponding Lys209 and Lys301 interact to form a so-called Lys-Lys trigger.

The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (1999, 55, 1805-1813) copyright 1999.