|
Figure 6.
Fig. 6. Superpositionoftheatomiccoordinatesofbrinzolamide(Azoptm;
AL4862, Kd = 0.13 nM) anddorzolamide(Trusoptm, Ki 0.37 nM, Greer
et l., 994; Smithet al., 1994). thetwonewest CAII inhibitorsappoved
for the treatmentofglaucoma.Brinzolamideisred;dorzolaide is green.
Forclarity,onlytheproteinatomsoCAII in the CAII-L4862 (brizola-
mide)complex are shown(yellow).Notethatthesix-memberedthiazene
ring of rizolamideadopts a half-chair,conformation,whereasthesix-
membeedthienoringofdorzolamideadopts a half-chair2conformation.
|
