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Figure 6.
Figure 6. Hypothetical Model of Some Steps in the Membrane
Fusion Mechanism(A) and (B) represent hypothetical intermediates
and are based on Figure 3 of [70] (see text). Fusion peptides
labeled F are colored red. GP2 transmembrane anchors are labeled
A. The GP2 outer layer α helices are colored light blue; the
N-terminal, core coiled coil is dark blue; disulfide bonds are
yellow. Ngp2 and Ngp1 label the proposed location of the N
termini of those polypeptide chains. The gray spheres represent
the receptor-binding domain of GP1. The picture also
incorporates suggestions that more than one trimer might be
involved in forming an initial fusion pore ( [22]) and that the
bilayers may be distorted with molecules entering at an angle (
[51 and 65]), which in some way results in distortions to the
membrane that favor membrane fusion (e.g. [17]).
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