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Figure 8.
Figure 8. Stereoviews of base stacking and intermolecular hydrogen bonding pattern in a representative relaxation
matrix refined structure (RM-B1) of the MC-DNA 9-mer complex. A, The d(C4-[MC]G5) · d(C14-G15) step with the
mitomycin shown in cyan. An intermolecular hydrogen bond is shown between the exposed amino proton of dG15 and
the ester oxygen attached to C-10" on the mitomycin. We observe cross strand stacking between the base planes of [MC]dG5
and dG15 at this step. B, The d([MC]G5-T6) · d(A13-C14) step with the mitomycin shown in cyan. We observe stacking
between the base planes of [MC]dG5 and dT6 and the base planes of dA13 and dC14 within individual strands.
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