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Figure 6.
Fig. 6. Illustrations of the electrostatic surface and
intermodular interface of fH12–13. (a) Electrostatic
surface^43 (top; same view as in Fig. 3e); CCP 12 is
predominantly electronegative, whilst the linker and CCP 13
display an electropositive patch that includes the helix-like
hypervariable region. (b) In this cartoon (PyMOL), disulphides
are drawn as sticks (yellow sulphur atoms), CCP 12 is shown in
red, CCP 13 is shown in blue, and linker is shown in
yellow/orange. Different shades of these colours are used to
distinguish side chains (drawn as spheres; heavy atoms only)
contributing to the intermodular interface. Side chains are
labelled in the blow-up (bottom).
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