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Figure 6.
Fig. 6. Modular architecture of Hia and putative two-step
adhesive mechanism. (a) Modular architecture of Hia adhesin.
While the structures of IN1, W1, KG1, W3, IN2, W5, Neck, and
transmembrane anchor/translocator domains are determined
crystallographically, W2/W4 and KG2 are modeled based on
W1/W3/W5 and KG1, respectively. Yellow rectangles represent the
Hia sequences that are yet to be structurally characterized,
including the predicted N-terminal GANG and C-terminal TTT
domains. (b) A putative two-step adhesive mechanism utilized by
Hia/Hsf-like adhesin to form an intimate association between the
bacterium and the host cell. The adhesive Trp-ring domains with
different binding capacities are shown in blue and red. The
nonadhesive Trp-ring domains are shown in green.
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