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Figure 6.
Figure 6. Schematic for EF-G and Thiopeptide Action during
Translation
(A–D) Model for events leading to EF-G
accommodation on the ribosome and Pi release as described in the
text. Effect of (E) Thio (purple) and (F) Micro (brown) are also
shown schematically. Individual domains of EF-G (orange) are
labeled with II-V and G/G′, and the stalk base (SB) components
are indicated with L11 (green) divided into with N- and
C-terminal domains (NTD, CTD) and rRNA helices H43 and H44
(blue). The C-terminal domain of L7 (L7-CTD) is shown in red.
Note that for simplicity, the switching mechanism has been
divided into two distinct steps; however, it is unclear as to
whether they are sequential, as shown here, or occur
simultaneously.
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