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Figure 6.
Figure 6. Overlay of the XIP-I/P. funiculosum GH11 xylanase
complex with wild-type and mutant NpXyn11A. (a) The structure of
the XIP-I (green)/P. funiculosum GH11 xylanase (red) complex was
overlaid with wild-type NpXyn11A (cyan). The loops connecting β
strand 3 with 4 and β strand 11 with 12 appear to clash with
the xylanase inhibitor. (b) Wild-type NpXyn11 (cyan) and the
Δ3-4NpXyn11A mutant (magenta) were overlaid with the structure
of XIP-I when in complex with the P. funiculosum GH11 xylanase.
The mutation has reduced the size of the loop connecting β
strands 3 and 4, which now no longer make steric clashes with
XIP-I.
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