Figure 6.
(a) Cluster analysis of the N-CoR-R1 complex with ETO-TAFH.
Two clusters are seen, with the lowest-energy cluster circled,
representing 75%
of the 200 water-refined structures from HADDOCK (see Methods).
(b) Stereo view of representative model from the lowest-energy
cluster in a. Black band, Leu387 of N-CoR-R1. Light shading,
positions of mutations in ETO-TAFH that disrupt interaction with
N-CoR-R1 or HEB-AD1, as discussed in the text.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2007,
14,
653-661)
copyright 2007.
75%
of the 200 water-refined structures from HADDOCK (see Methods).
(b) Stereo view of representative model from the lowest-energy
cluster in a. Black band, Leu387 of N-CoR-R1. Light shading,
positions of mutations in ETO-TAFH that disrupt interaction with
N-CoR-R1 or HEB-AD1, as discussed in the text.