Figure 6.
FIGURE 6. Bound conformations of saturated and unsaturated
IZD-phenyl moieties. a, the relative angle between the
unsaturated IZD and phenyl rings of 1 is 70-75°. b,
superposition of the unsaturated IZD 1 (stick bonds) and the
saturated (S)-IZD-phenyl moiety of 2 (ball-and-stick). Note the
phenyl ring and heteroatoms of IZD bind in the same position
whether or not the heterocycle is reduced.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2006,
281,
32784-32795)
copyright 2006.
70-75°. b,
superposition of the unsaturated IZD 1 (stick bonds) and the
saturated (S)-IZD-phenyl moiety of 2 (ball-and-stick). Note the
phenyl ring and heteroatoms of IZD bind in the same position
whether or not the heterocycle is reduced.