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Figure 6.
Figure 6. The conformational change in the P-loop of Sa_ArsC
(a) The 2F[o]–F[c] electron density map contoured at 1σ of
the P-loop of Sa_ArsC C10SC15A (PDB code 2FXI). (b) The P-loop
active site of Sa_ArsC C10SC15A harbouring a sulphate molecule
(PDB code 2FXI) (green) with the peptide bond between Gly12 and
Asn13 in a left-handed α[L] conformation. On top is the P-loop
(PDB code 1JFV)^8 (salmon) that binds a perchlorate (not shown)
with the peptide bond between Gly12 and Asn13 flipped to a β
conformation is visualized. Structures were superposed with the
SSM algorithm.^21 Figures were generated by using MacPyMol
(Delano Scientific LLC 2005).
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