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Figure 6.
Figure 6. Evolution of the Switch Regions along the Path for
GTP Hydrolysis
(A–D) Backbone atoms of both switch 1
(pink, residues 25–40) and switch 2 (yellow, residues 57–75)
are shown along with key side chain residues for simplicity. The
guanine nucleotide (GTP/GDP) and the Mg^2+ ion are shown in a
ball-and-stick model. (A) The beginning of the path (Ras•GTP)
(Pai et al., 1990). (B) Transient intermediate 1 (RasQ61G). (C)
Transient intermediate 2 (RasA59G) (Hall et al., 2002). (D) The
end of the path (Ras•GDP) (Milburn et al., 1990). Hydrogen
bonds between switch regions and other key hydrogen bonds are
denoted by dotted lines.
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