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Figure 6.
Figure 6 Interaction surface between activin and Fs12 and
ActRIIB. Comparison of activin binding by Fs12 and the
extracellular domain of the type II activin receptor (Greenwald
et al, 2004; PDB:1s4y). Activin protomers are shown as molecular
surfaces (orange and red), and the two Fs12 molecules (A, blue
Fs1 and green Fs2) and two type II receptor domains (B, blue and
green) are shown as ribbon diagrams. The activin surface is
coloured dark grey over atoms that are closer than 4 Å
from the interacting protein. Water molecules sandwiched between
the two proteins are shown as light blue spheres. Both complexes
are shown in the same orientation for the orange activin A
protomer.
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