|
Figure 6.
FIGURE 6. Active site of HSV-1 D88N/H210N UNG. A, the amino
acid residues in the active site of HSV-1 D88N/H210N UNG (green,
carbons; blue, nitrogen; red, oxygens) are aligned with those of
the wild-type enzyme (purple). Electron density for HSV-1
D88N/H210N UNG is shown. B, HSV-1 D88N/H210N UNG with uridine
bound in the active site is aligned with the wild-type enzyme
with uracil bound in the active site (purple). Electron density
for HSV-1 D88N/H210N UNG is shown. C, hydrogen bond distances
between the residues in the HSV-1 D88N/H210N UNG active site and
the bound uracil are shown in red, whereas those in the active
site of the wild-type enzyme are shown in black.
|
