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Figure 6.
Figure 6 Proposed mechanism for receptor-mediated activation of
HSV gD. Envelope gD is shown, as a putative dimer, in its
unbound state as well as during interaction with HVEM (top) or
nectin-1 (bottom). Conformational changes are chronologically
indicated by numbered arrows: (1) displacement of the
C-terminus, (2) folding of the gD N-terminus in the case of HVEM
binding, and (3) exposure of the PFD. The N-terminus of gD is
shown in green, the C-terminus (290-299) is colored red, and the
PFD (260-285) is pink.
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