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Figure 6.
Figure 6. Protease-inhibitor interactions. Only the
residues involved in hydrogen bond interactions are shown. Water
molecules are represented as spheres. Hydrogen bonds are
indicated by broken lines. (a) PR[L24I] hydrogen bond
interactions with indinavir. Water molecules are labeled A-D.
(b) Interactions of Arg8' with the pyridyl group of indinavir in
PR[I50V]-IDV. The omit map is contoured at 3.5s. (c) PR[L24I]
interactions with p2/NC. Water molecules are labeled 1-8. Arg8
and Arg8' are omitted for clarity. (d) Selected interactions of
the side-chains of Ile/Leu50 and 50' with indinavir in the
PR[I50V] and PR indinavir complexes. PR-IDV is in green and
PR[I50V]-IDV is red. Only the central portion of indinavir is
shown with van der Waals contacts indicated by dotted lines with
distances in Å.
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