Figure 6 - full size

 

Figure 6.
Figure 6 Details of the interaction of the KH domains with RNA11. (A) Interaction of KH1 with nucleotides Ade42 to Ura46 in the / groove of helices 2, 3 and 1- 3 of the KH1 domain. (B) A view highlighting the protein-nucleic acid interactions around Ade44 and Ade45. The protein is shown as a green ribbon. The hydrogen bonds of Ade44 to the backbone are shown together with the interactions of the 2'-hydroxy group of Ade45. (C) Stereo view of the interactions of Ade50, Ura51 and Ade52 with the protein. The path of the RNA along the groove of '2/ '3 and '3 in KH2 is shown. (D) Highlights of the network of polar interactions around Ade50 to Ade52. The protein and RNA are represented as in panel B.

The above figure is reprinted by permission from Macmillan Publishers Ltd: EMBO J (2005, 24, 3576-3587) copyright 2005.