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Figure 6.
FIG. 6. Solvent arrangements in the ligand binding cavity
of unliganded GRP94. A, stereo drawing of the residues lining
the cavity and the solvent molecules within the cavity. Hydrogen
bonds are shown as dashed lines. Water molecules are shown as
spheres, and those that are common to all GRP94-ligand complexes
are colored purple. Orange-colored waters are conserved in the
GRP94 closed conformation but are displaced by nucleotides and
the large inhibitor geldanamycin. PEG, polyethylene glycol. B,
schematic diagram of the same interactions shown in panel A.
Water molecules are colored as in panel A. Hydrogen bonds are
shown as green dashed lines. NE, nuclear extract.
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