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Figure 6.
Figure 6. The T-Rex NAD(H) Binding Sites and Comparison
with NAD(H)-Dependent Dehydrogenase
(A) T-Rex interactions
with the NADH effector molecule, in the conformation with Phe189
inserted between the nicotinamide rings. Average distances
between interacting atoms of the three subunits exhibiting this
conformation are indicated.
(B) T-Rex interactions with the
NADH' molecule bound to the opposite subunit, in the
conformation with Phe189 folded back and buried within the
hydrophobic core.
(C) LADH interactions with bound NADH,
zinc ion (ZN), and DMSO substrate.
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