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Figure 6.
Fig. 6. The environment of the hydrophobic benzyl extension
of GC-24. GC-24 and surrounding side chains are shown in beige,
and GC-1 is shown in blue. (a) Residues most changed by GC-24
binding are found at the start of helix 3 and the C terminus of
helix 11. (b) Phe-451, Pro-452, Phe-455, and, to a lesser
extent, Ile-276 (residue not shown) enhance the hydrophobic
cluster linking helix 11 and helix 12 to the receptor core only
in GC-24. The benzyl participates in close packing interactions
with six hydrophobic side chains.
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