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Figure 6.
FIG. 6. The solvent-accessible surface model of iGDase and
GAs around the substrate binding pocket. a, iGDase (PDB ID: 1ULV
[PDB]
). Gln-380 does not directly interact with acarbose, and
constriction of Trp-582 is observed. b, T. thermosaccharolyticum
GA (1LF9 [PDB]
). Trp-390 is stacked with acarbose, and the constriction of
Tyr-590 is not seen. c, A. awamori var. X-100 (1AGM [PDB]
). An extended loop consisting of five amino acid residues
(TGSWG), which are not conserved in iGDase and T.
thermosaccharolyticum GA, interacts with acarbose.
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