Figure 6.
Figure 6. Comparison of hydrogen-bonding networks at the Ly49C
-H-2Kb and Ly49A -H-2D^d interfaces. (a) Detailed view
(stereo diagram) of the Ly49C -H-2Kb interface showing hydrogen
bonds (dotted black lines) between Ly49C (red) and the H-2Kb
heavy chain (blue) or [2]M
(violet); the side chains of interacting residues are yellow.
The portion of the Ly49C L3 loop, encompassing residues 226
-231, which is disordered in both mutant and wild-type
structures, is drawn arbitrarily (red balls). With the exception
of H-2Kb residues Asp212 and Thr214, whose side chains could
potentially interact with the disordered L3 loop of Ly49C, only
residues forming hydrogen bonds are shown. (b) Stereo diagram
showing hydrogen bonds between Ly49A (green) and the H-2D^d
heavy chain (blue) or [2]M
(violet) at the site 2 interface of the Ly49A -H-2D^d complex.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Immunol
(2003,
4,
1213-1222)
copyright 2003.
[2]M
(violet); the side chains of interacting residues are yellow.
The portion of the Ly49C L3 loop, encompassing residues 226
-231, which is disordered in both mutant and wild-type
structures, is drawn arbitrarily (red balls). With the exception
of H-2Kb residues Asp212 and Thr214, whose side chains could
potentially interact with the disordered L3 loop of Ly49C, only
residues forming hydrogen bonds are shown. (b) Stereo diagram
showing hydrogen bonds between Ly49A (green) and the H-2D^d
heavy chain (blue) or