Figure 6 - full size

Figure 6. Figure 6. Different Domain Orientations in Autoinhibited Structures of sEGFR and sErbB3The structures of autoinhibited sEGFR and sErbB3 (Cho and Leahy, 2002) were overlaid by superimposition of domains III and IV.(A) The sEGFR/sErbB3 overlay is shown in the orientation used for sEGFR in Figure 1A. sEGFR is gray; sErbB3 is magenta.(B) The same sEGFR/sErbB3 overlay is shown in an orthogonal view to illustrate the different orientation of the domain I/II fragment in the two structures. The difference is approximated by a 60° rotation about the axis marked with a black circle.

The above figure is reprinted by permission from Cell Press: Mol Cell (2003, 11, 507-517) copyright 2003.