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Figure 6.
Figure 6. The proposed roles of K53, K110 and E159 of sIGPS
in catalyzing the conversion of CdRP to IGP. Hydrogen bond
distances are given in Table 3. (*) Asymmetric carbon atoms
generated transiently. The arrows show how the reactions are
assisted by the indicated catalytic residues. See the text for
details. (a) The substrate bound unproductively as observed in
the sIGPS:CdRP complex ( Figure 3(c)), with C1-C2' DISTANCE=4.8
Å. (b) The intermediate I1 as in Figure 5(a). (c) The
intermediate I2 as in Figure 5(b). (d) The sIGPS:IGP complex as
in Figure 3(b).
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