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Figure 6.
Figure 6. Comparison of the crystal structure of
EPO-R-bound EMP-1 with EMP-18b and EPO-3 in solution. The
minimized mean structures of EMP-18b (green) and EPO-3 (cyan)
were superimposed on the crystal structure (pink; PDB accession
code 1ebp chain D) using the N, C^a and C atoms of residues
Cys2-Phe4 and Trp9 to Cys11 (EPO-3 numbering). The C^a of the
residues corresponding to Phe4 and Trp9 of EPO-3 are shown as
spheres, and the carbonyl oxygen atoms of the turn residues are
colored red. The EPO-R atoms that donate a hydrogen bond to the
peptide EMP-1 in the complex are indicated.
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