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Figure 6.
Figure 6 Hypothetical model of Bcl-3 bound to a DNA-bound p50
homodimer. The model was constructed based on the structure of
the I  B
 -NF
B
complex, by structurally aligning Bcl-3 (yellow) onto I B
(red)
and a DNA-bound p50 homodimer (green and blue; Müller et al.,
1995) onto the p50 -p65 heterodimer (not shown, although it is
nearly identical to the p50 homodimer, where the green monomer
corresponds to the p65 subunit). A 30-base pair stretch of ideal
B-form DNA was then superimposed onto the shorter duplex present
in the p50 -DNA crystal structure. (A) Side view showing that
sufficient space is available next to the DNA to accommodate ANK
repeat 7 of Bcl-3 but not the PEST region of I B
.
(B) View showing that the C-terminal domains of I B
and
Bcl-3 are positioned on opposite sides of the ARD. The view is
that of (A) rotated by 110° about the vertical axis.
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