Figure 6 - full size

 

Figure 6.
Fig. 6. Superimposition of the crystal structures of IV703 bound to TNFRc1 (purple, this study) and that of TNF- bound to TNFRc1 (green; ref. 11). Note that Tyr-108 (TNF- ) normally interacts with Ala-62 (TNFRc1) (11); this receptor residue is bound to IV703 in our structure.