|
Figure 6.
Figure 6. Superposition of VCP  vert,
similar 2,3 and VCP vert,
similar 3,4 [Wiles et al 1997] using module 3. (a) A randomly
selected sample of 25 structures from each of the VCP vert,
similar 2,3 (cyan) and VCP vert,
similar 3,4 (dark blue) sets of NMR structures. All structures
are superimposed on the backbone of module 3 of the structure of
VCP vert,
similar 2,3 most similar to the average structure. Backbone
atoms are shown. (b) A surface representation of VCP vert,
similar 2,3 (module 2, cyan; module 3, light blue) and module 4
(dark blue) of VCP vert,
similar 3,4. The orientation of all modules is the same as in
6(a). The side-chains of 11 residues that are replaced in the
sequence of SPICE are coloured red, and labelled (and SPICE
replacements shown in parantheses). VCP vert,
similar 2,3 numbering is used except for substitutions in module
4 (italics) where VCP vert,
similar 3,4 numbering is used.
|
