Figure 6 - full size

 

Figure 6.
Figure 6. Stereo representation of two clusters of negatively charged residues in hv-DHFR. Water molecules are depicted as black spheres and hydrogen bonds as dashed lines. (a) Intramolecular cluster; (b) intermolecular cluster at the interface of three molecules.

The above figure is reprinted by permission from Cell Press: Structure (1998, 6, 75-88) copyright 1998.