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Figure 5.
Fig. 5. Stereoview comparisons of the H3 loops in B1-8 and
B1-8/NQ11. (a) A worm representation of the H3 loop in B1-8
(shaded lighter) superimposed on the H3 loop of B1-8/NQ11
(shaded darker). The^ molecular surface shown is that of the
B1-8/NQ11 model with the^ H3 loop omitted. The surface of the
V[H] domain is white and the^ general surface of the V[L] domain
is light gray. The surface of^ Phe^L60 is shaded dark. The
analogous residue in B1-8 is Ala^L57 that leaves space to
accommodate the side chain of TyrH106 (shown in stick
representation) in the B1-8 Fv. The presence^ of GlyL96 (shaded)
leaves space to accommodate the side chain of TyrH106 in
B1-8/NQ11. The analogous volume in B1-8 is occupied by TrpL93.
(b) The H3 loop of B1-8/NQ11 and its interaction with V[  ]residues.
The C^  positions
are indicated with larger spheres. V[L] atoms are shown as white
spheres and V[H] atoms as black spheres. (c) The B1-8 H3^ loop
and its interactions with the V[  ]domain.
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