Figure 5 - full size

Figure 5. Figure 5. Surface representations of the substrate-free and EP-UDP-GlcNAc-bound MurB structures. (a) Molecular and charge surfaces of the substrate-free MurB with a view of the uracil portion of the bound flavin. This representation shows access to the flavin and the charge distribution at the channel (positively charged areas shown in blue, negatively charged areas shown in red, and neutral areas shown in white). (b) The EP-UDP-GlcNAc–MurB complex. The substrate-bound MurB shows structural and charge-distribution changes induced upon substrate binding. Figure 5. Surface representations of the substrate-free and EP-UDP-GlcNAc-bound MurB structures. (a) Molecular and charge surfaces of the substrate-free MurB with a view of the uracil portion of the bound flavin. This representation shows access to the flavin and the charge distribution at the channel (positively charged areas shown in blue, negatively charged areas shown in red, and neutral areas shown in white). (b) The EP-UDP-GlcNAc–MurB complex. The substrate-bound MurB shows structural and charge-distribution changes induced upon substrate binding. (Figure generated using GRASP [[4]27].)

The above figure is reprinted by permission from Cell Press: Structure (1996, 4, 47-54) copyright 1996.