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Figure 5.
l-Arginine-induced quaternary structure changes of hexamer. A
and B, simplified model showing the molecular hexamer in two
different orientations. Different subunits are shown in
different colors. K and S refer to AAK and NAT domains,
respectively, and the numbers are used to distinguish subunits.
The two types of AAK interfaces that link the trimers are
illustrated by the interactions between K1 and K4 and between K1
and K5. In addition, monomers within trimers interact via
interactions between AAK and NAT domains of adjacent subunits,
for example K2 and S1. C, detailed view of interactions between
AAK domain K2 and NAT domain S1 for R-state (left panel) and
T-state (right panel).
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