Figure 5.
Figure 5. (a) FK506 (from PDB 1FKF) modeled in the
ligand-binding pocket of wild-type (violet) and E60Q (cyan)
FKBP12. The rotation of W59 leads to a conformation that creates
steric clash between its side chain and the docked FK506. (b)
The network of interacting amino acids and Wat3 in FKBP12.
The above figure is reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2008,
74,
603-611)
copyright 2008.
