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Figure 5.
FIGURE 5. The active sites of HDAC4 and HDAC8. A, the
active site of HDAC8 (yellow side chains) bound to a hydroxamic
acid inhibitor (light brown) from Protein Data Bank entry 1W22
[PDB]
. B, WT HDAC4cd with bound TFMK (yellow carbons) (Protein Data
Bank code 2VQQ) and superposed HA (green carbons) (Protein Data
Bank code 2VQM). The active site closely resembles HDAC8. C, the
active site of GOF HDAC4cd with HA bound (Protein Data Bank code
2VQV); Tyr^976 adopts the inward, class I-like conformation. D,
the active site of GOF HDAC4cd with TFMK bound (Protein Data
Bank code 2VQO); Tyr^976 adopts an outward conformation.
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