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Figure 5.
Comparison of the crystal structures of PR (red)- and
PR[D25N] (green)-inhibitor complexes. Tube representations of PR
bound to DRV (A) or RPB (B) superimposed on PR[D25N] bound to
DRV (A) or RPB (B) ranging from 1.05- to 1.4-Å resolution.
Inhibitors, DRV and RPB, and the active site residue 25 are
shown as stick models, and the terminal residues are indicated.
The location of a central motif consisting of a hydroxyl group
in DRV that can hydrogen bond to the catalytic Asp-25 is
indicated by the black arrow.
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