Figure 5 - full size

 

Figure 5.
FIGURE 5. The native TSPN-1 structure in P1 space group. A, a ribbon drawing of the two TSPN-1 domains in one asymmetric unit. They are not related by any pseudo-symmetric operation. Residue Arg-42 from the major heparin-binding site of each domain is drawn in ball-and-stick form. The two TSPN-1 domains interact with each other extensively through their edge strands (see "Results"). The electric dipole moment of the two TSPN-1 domains is shown by the blue arrow and centered at the beginning of the arrow. B, an electrostatic potential surface representation of the two TSPN-1 domains in the native TSPN-1 structure. Residue Arg-42 from the major heparin-binding site of each TSPN-1 domain is labeled to show the separation of the two major heparin-binding sites in this native structure. The orientation of the figure is similar to the one shown in panel A.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2007, 283, 3932-3941) copyright 2007.