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Figure 5.
FIGURE 5. Comparison of CAO xenon binding sites. a, overlay
of CAO xenon sites deposited in the PDB with a monomer of the
HPAO/Xe complex. The backbone of HPAO is displayed and colored
by domain: blue stick, D1; yellow stick, D2; green ribbon, D3.
Xenon sites from individual complexes are coded by color (red,
PSAO (PDB code 1w2z); yellow, PPLO (PDB code 1rky); blue, AGAO
(PDB code 1rjo) magenta, HPAO (PDB code 2oqe)), except
surface-bound xenon sites, which are displayed as gray spheres
(31). The top inset shows the amine channel. The bottom inset
shows a proposed molecular oxygen pathway identified in this
study. The active site is shown in stick, and the copper is
shown as a green sphere. b, the HPAO D3  -sandwich domain viewed
from the dimer interface (90° rotation, cf. view in a). Only
the xenon sites in the internal D3 -sandwich and close to
the anteroom are shown. Colors are the same as in a, and arrows
indicate the direction of molecular oxygen movement to the
active site using the proposed pathway. The figure was generated
using Pymol (20).
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