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Figure 5.
Figure 5. Schematic representation of the BenM-EBD
effector-binding sites. (a) Muconate in the primary site.
Hydrogen bonds (between non-hydrogen atoms) to the effector are
shown as broken lines. The distance between the O1 of muconate
and the Arg146 N^ε atom is also shown (dash-dot). Helices,
colored as in Figure 2, are shown as cylinders. β-Strands were
omitted for clarity. (b) Benzoate in the secondary site. H1 is a
3[10]-helix associated with both binding sites. (c) Residues
implicated in the charge relay postulated to be responsible for
synergistic activation.
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