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Figure 5.
Figure 5.Conformational Changes in the TM Region of AcrB
(A) Wire model of the superpositioned TM domains of subunit A
and subunit C viewed from the periplasmic side. Subunit B is
omitted since it displays a similar conformation as subunit A.
The individual helices are labeled.
(B) Detailed
interactions of the amino acid residues in the putative
proton-translocation site viewed in the same orientation as in
(A). Residues involved in the hydrogen-bonded network (dashed
lines) are labeled. The |Fo-Fc| omit electron density map (blue
mesh) of Lys940 in subunit C is contoured at 3.5 σ.
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