Figure 5 - full size

 

Figure 5.
Figure 5. Primer extension by Pol and Pol from T or C opposite the dA adduct. DNA substrate is shown above; asterisk indicates the site of either an A or an dA residue in the template; Y at the primer terminus denotes either T or C opposite the undamaged A or the dA template residue. Each protein (1 nM) was incubated with DNA substrate (10 nM) and all four dNTPs (50 M).

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Mol Biol (2006, 13, 619-625) copyright 2006.