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Figure 5.
Fig. 5. Comparison of the ubiquitin-binding surfaces of
HAUSP, USP14, and PLpro based on modeling studies. For modeling
ubiquitin into the SARS-CoV PLpro active site, the structures of
the Ubal-bound forms of HAUSP (1nbf) and USP14 (2ayo) were
superimposed onto the PLpro structure and analyzed. Contacts at
the C-terminal tail of ubiquitin and two interacting surfaces of
the PLpro palm domain were manually edited and minimized by
using CNS. The ubiquitin molecule is shown as a ribbon diagram.
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