|
Figure 5.
Fig. 5. Stereo plot illustrating the tight loop forming
the S2 binding site. Red is SPRK, green is PRK and blue is VPRK.
Labels and distances in the loop refer to SPRK. The stabilizing
hydrogen bonding network formed by residues Asn97, Ser99 and
Ser101 in SPRK is displayed as ball-and-stick models. A similar
network is not as strong in PRK and VPRK due to a shorter Ser97
in VPRK and a too-long Asn99 in PRK. The loop is anchored to the
rest of the molecule in SPRK and VPRK by a disulfide bridge
between Cys98 and Cys66 (Asp98 in PRK). The catalytic His69 is
displayed as ball-and-stick model in order to illustrate the
orientation of the loop relative to the binding site.
|
