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Figure 5.
Figure 5 Two models for ion conduction. Schematic drawing of ion
conduction in a single ion pore and a multiple-ion pore. (A)
Single-ion pore: The selectivity filter binds only one ion at a
time. During permeation the ion enters the selectivity filter
from the solution and diffuses between the different binding
sites of the channels until it dissociated from the filter. (B)
Multiple-ion pore: The selectivity filter binds multiple ions,
which permeate in a single file when additional ions enter the
filter. The filter is depicted in its open state; the ions are
drawn as spheres.
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