Figure 5.
Figure 5: The alpha-'NT
region (residues 727-744) slips through the beta--ring.
a, Two views, rotated by 180°, of the cone formed by ANA, MG3
and MG8 (surface representation), and residues 730-744 (stick
representation). Residues important for factor B binding are
labelled. b, The 'NT
regions are on opposite sides of the molecule in C3 and C3c. In
C3 this region is covalently linked to ANA; the scissile bond
726-727 is part of a disordered loop 720-729 (dashed line). Also
shown are surface contours of C3 and C3c (transparent light
grey), residues 727-767 (green sticks), ANA and MG6 (ribbons),
and MG2 and MG3 of the -ring
(spheres).
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2005,
437,
505-511)
copyright 2005.
'NT
region (residues 727-744) slips through the beta-
-ring.
a, Two views, rotated by 180°, of the cone formed by ANA, MG3
and MG8 (surface representation), and residues 730-744 (stick
representation). Residues important for factor B binding are
labelled. b, The 
'NT
regions are on opposite sides of the molecule in C3 and C3c. In
C3 this region is covalently linked to ANA; the scissile bond
726-727 is part of a disordered loop 720-729 (dashed line). Also
shown are surface contours of C3 and C3c (transparent light
grey), residues 727-767 (green sticks), ANA and MG6 (ribbons),
and MG2 and MG3 of the 
-ring
(spheres).