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Figure 5.
Fig. 5. Active site cavities in hMAO A and hMAO B. (A) The
surface of active site cavity in hMAO A is shown in red
chicken-wire representation in the same orientation as in Fig.
3. Clorgyline is depicted in black. (B) Active site comparison
of hMAO A and hMAO B with the crucial Phe-208 and Ile-335
residues of hMAO A superimposed to the corresponding Ile-199 and
Tyr-326 residues of hMAO B. The protein and inhibitor atoms of
hMAO B are in red. With respect to A, the model has been rotated
by  90° around the
vertical axis in the plane of the drawing. (C) The active site
cavity (red surface) of hMAO B in complex with deprenyl (black)
is depicted in the same orientation as in A.
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