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Figure 5.
FIG. 5. Model of KD1 with plasmin. Plasmin is shown with
cyan ribbons, and KD1 is shown with yellow ribbons. A,
KD1·plasmin hydrophobic interface. The hydrophobic patch
in KD1 composed of Leu-17, Leu-18, Leu-19, and Leu-34 is shown
interacting with a hydrophobic patch in plasmin consisting of
Phe-37 {583}, Met-39 {585}, and Phe-41 {587}. B, Arg-20 and
Tyr-46 of KD1 interactions with plasmin. As compared with
interactions in the KD1·trypsin complex, Arg-20 of KD1
directly interacts with Glu-60 {606} of plasmin, and Tyr-46 of
KD1 interacts with Lys-60A {607} and Arg-60D {610} in plasmin.
C, Glu-39 of KD1 interactions with plasmin. Glu-39 of the acidic
patch in KD1 interacts directly with Arg-175 {719} and possibly
through water molecules to Arg-100 {644} and Arg-221 {767} of
the basic patch in plasmin.
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