Figure 5 - full size

 

Figure 5.
Figure 5 (a) Stereoview in ball-and-stick representation with sticks coloured blue and yellow for the molecules that form the crystal contact. The mutation K133I favors the formation of the crystal contact with mainly hydrophobic interactions. A lysine side chain at this position would cause steric clashes and disable this crystal packing.

The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (2005, 61, 513-519) copyright 2005.