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Figure 5.
Figure 5
(a) View of the Arg22 contacts for L22R mDHFR. Drawn with LIGPLOT (Wallace et al.,
1995[236] [Wallace, A. C., Laskowski, R. A. & Thornton, J. M. (1995). Protein Eng. 8,
127-134.]-[237][bluearr.gif] ). (b) View of the contacts to MTX for L22R mDHFR-MTX-NADPH
complex. Note: Glu30 makes a hydrogen-bonding contact to MTX N1 and N2 that is not shown
in this projection. Drawn with LIGPLOT (Wallace et al., 1995[238] [Wallace, A. C.,
Laskowski, R. A. & Thornton, J. M. (1995). Protein Eng. 8, 127-134.]-[239][bluearr.gif] ).
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