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Figure 6.
Figure 6. TFIIS-Induced RNA RealignmentSelected elements in
the pol II active center that move upon TFIIS binding are shown.
The bridge helix, DNA, and RNA in the pol II-bubble-RNA-TFIIS
complex are in green, blue, and red, respectively. The TFIIS
hairpin is in orange with the two acidic functionally essential
and invariant residues in green. Nucleic acids in the pol
II-bubble-RNA complex structure after superposition of residues
in the active site aspartate loop or in switch 2 are shown in
beige and gray, respectively. Switch 2 moves slightly upon TFIIS
binding (Kettenberger et al., 2003), explaining the difference
in the two superpositions.
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